Organtrans

Brief Description & Goal

Coordinated by CSEM, eight consortium members will create a standardized and automated tissue preparation and maturation platform, which will provide patients with End-Stage Liver Disease (ESLD) an alternative to donor organ transplants. Adult stem cells can be taken from healthy residual liver tissue of patients, isolated and even organized into organoids. These are then assembled by printing and allowed to mature in a unique combination bioreactor. This procedure enables the production of a personalized tissue engineered autologous liver that is tailored to the patient. The platform technologies can later be scaled up to other organ systems and therapeutic approaches in regenerative medicine.

The aim of the project is creating an alternative to organ donation for liver repair and the translation of the novel 3D liver tissue construct for transplantation into clinical application.

Our Role

Kugelmeiers has long-standing experience in the field of scaffold-free 3D cell culture and the production, handling and cultivation of (stem cell-based) spheroids. With the Sphericalplate 5D, the company has developed a translational platform for upscaling of standardized spheroids of any type and size. In addition, an internal team of regulatory specialists is accompanying the project in order to prepare the approval of the developed medical devices and cell products as a clinical therapy for the treatment of ESLD.

Project Partners